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From 0.5 to 2.5 m² of shelf area
Condenser capacity up to 40 kg
Output for 2R up to 10,000 vials

GMP production equipment for small batches

Compact construction complying with GMP

CIP / SIP equipment

Wide range of optional equipment

Panels for clean rooms


Designed for aseptic batches. Compact and adaptable.

During pharmaceutical and biotechnological development, high value-added and personalized configuration products require a highly demanding process in small batches and in full compliance with regulations and procedures.

The LyoNano model is the best choice for customers developing processes for high value products. It is equipped with technology available in our commercial units but for smaller batch sizes and is in full compliance with commercial regulation and procedure.

Shelf area0.5 m²1 m²1.5 m²2 m²
Shelf dimensions (W x D)380 x 450 mm
Nº of shelves3 + 16 + 19 + 112 + 1
Shelves clearance90 mm75 mm90 mm65 mm
Chamber materialStainless steel AISI 316L
Condenser capacity30 kg30 kg40 kg40 kg
Condenser temperature-85 ºC
Shelves temperature rangefrom - 60 ºC to +85 ºC
Overall dimensions (W x D x H)1,600 x 1,300 x 1,800 mm2,500 x 1,300 x 1,800 mm
Weight1,500 kg2,000 kg2,500 kg3,000 kg

Optional equipment

The chamber

  • Rectangular chamber

  • Pressureless vessel

  • Injected foam insulation

  • Cooling by cold water circuit

Connection with condenser

  • Butterfly valve

  • Mushroom valve

  • Bottom shelf closing

Ice condenser

  • Integrated underneath, on the same floor

  • Integrated on the side, on the same floor

  • Outside, behind the camera, on the same floor

  • Outside, under the camera, on another floor

Shelves movement

  • Closing system hydraulic piston

  • Bellows

  • Connection with the automatic charging system


  • Chamber and condenser cleaning system

  • Recirculation system with heating

  • Multiple cleaning cycles


  • PED-EN13445

  • ASME

  • Chamber cool-down after SIP

Plant distribution

  • 1st floor

  • 2 floors

  • Passthrough system

Additional elements

  • ATEX (processed with solvents and alcohol)

  • Cold tray loading

  • Frozen tray loading

  • Nucleation technology


  • Piston compressor

  • Screw compressor

  • Liquid nitrogen system

  • Cascade system

  • Cooling system without PCA

  • Compressed air system


  • Full size door

  • Automatic locking

  • Slot front door (constant loading level)

  • Full size sub-door

  • Cooling by cold water circuit

Process sensors

  • Pirani

  • Capacitive

  • Temperature probes (Pt-100 / Thermocouple)

  • Redundant temperature probes (Pt-100 / Thermocouple)

  • Wireless temperature monitoring

  • Full batch traceability software

Control systems

  • Rockwell / Siemens Automation PLC

  • Integrated HMI


  • Electronic recorder

  • Electronic Server and Think Client

  • Cycle optimization technology

Filter vent system

  • Sterilizable

  • Ports for integrity testing

  • Secondary venting cycle

  • Secondary vent filter

  • Water filter integrity test

Vacuum system

  • Sealed vacuum pumps with blowing system

  • Redundancy (additional pump)

  • Dry pumps with blowing system

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