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From 7 to 15 m² of shelf area
Condenser capacity up to 250 kg
Output for 2R up to 65,000 vials

GMP production equipment for medium scale production

Single body chamber and condenser Mushroom valve as intermediate valve

Compact and modular design

Standalone frame for cooling system

Standalone frame for vacuum system


  • GMP freeze dryers for medium production scale
  • GMP freeze dryers for medium production scale
  • GMP freeze dryers for medium production scale
  • GMP freeze dryers for medium production scale
  • GMP freeze dryers for medium production scale
  • GMP freeze dryers for medium production scale

Optimal balance. Maximum flexibility to face new market challenges.

An increase in production volumes is always accom-panied by proportional manufacturing equipment sizing. Here, Coolvacuum offers the LyoCool range that represents a perfect balance between compact design and a cooling system capa-ble of managing large production batches.

LyoCool is distinguished by its flexibility and can operate with any type of product regardless of its freeze-drying characteristics. The LyoCool freeze dryer is designed to fit into existing production plants and can be configured for optimal production design.

Model LyoCool
Shelf area 7.2 m² 8.64 m² 10.08 m² 11.52 m² 12.96 m² 14.4 m²
Shelf dimensions (W x D) 1,200 x 1,200 mm
Nº of shelves 5 6 7 8 9 10
Shelves clearance 120 mm 105 mm 90 mm 110 mm 100 mm 90 mm
Chamber width 2,100 mm 2,100 mm
Chamber height  3,300 mm 3,600 mm
Condenser capacity 120 kg 150 kg 200 kg 200 kg 250 kg  250 kg
Condenser temperature  -85 ºC
Shelves temperature range from - 60 ºC to +85 ºC

Optional equipment

The chamber

  • Rectangular chamber

  • Pressureless vessel

  • Injected foam insulation

  • Cooling by cold water circuit

Connection with condenser

  • Butterfly valve

  • Mushroom valve

  • Bottom shelf closing

Ice condenser

  • Integrated underneath, on the same floor

  • Integrated on the side, on the same floor

  • Outside, behind the camera, on the same floor

  • Outside, under the camera, on another floor

Shelves movement

  • Closing system hydraulic piston

  • Bellows

  • Connection with the automatic charging system


  • Chamber and condenser cleaning system

  • Recirculation system with heating

  • Multiple cleaning cycles


  • PED-EN13445

  • ASME

  • Chamber cool-down after SIP

Plant distribution

  • 1st floor

  • 2 floors

  • Passthrough system

Additional elements

  • ATEX (processed with solvents and alcohol)

  • Cold tray loading

  • Frozen tray loading

  • Nucleation technology


  • Piston compressor

  • Screw compressor

  • Liquid nitrogen system

  • Cascade system

  • Cooling system without PCA

  • Compressed air system


  • Full size door

  • Automatic locking

  • Slot front door (constant loading level)

  • Full size sub-door

  • Cooling by cold water circuit

Process sensors

  • Pirani

  • Capacitive

  • Temperature probes (Pt-100 / Thermocouple)

  • Redundant temperature probes (Pt-100 / Thermocouple)

  • Wireless temperature monitoring

  • Full batch traceability software

Control systems

  • Rockwell / Siemens Automation PLC

  • Integrated HMI


  • Electronic recorder

  • Electronic Server and Think Client

  • Cycle optimization technology

Filter vent system

  • Sterilizable

  • Ports for integrity testing

  • Secondary venting cycle

  • Secondary vent filter

  • Water filter integrity test

Vacuum system

  • Sealed vacuum pumps with blowing system

  • Redundancy (additional pump)

  • Dry pumps with blowing system

Always at your disposal!

We look forward to assisting you with your projects and answering your questions and suggestions. Fill in this form and we will contact you as soon as possible.

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