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From 16 to 45 m² of shelf area
Condenser capacity up to 800 kg
Output for 2R up to 200,000 vials

GMP production equipment for large scale production

External condenser in 1 or 2 floor configuration

Mushroom or butterfly valve as intermediate valve

Continuous circular coil in condenser

Standalone frame for cooling system

Standalone frame for vacuum system

  • GMP freeze dryers for large production scale
  • GMP freeze dryers for large production scale
  • GMP freeze dryers for large production scale
  • GMP freeze dryers for large production scale
  • GMP freeze dryers for large production scale
  • GMP freeze dryers for large production scale

Maximum performance. Large-scale security and reliability.

Do you need a high-performance freeze dryer for large scale production? Coolvacuum offers a solution for this requirement, the model LyoPro. This freeze dryer enables safe, large-scale freeze drying and has easy-to-install design and maximum flexibility.

As the flagship of the Coolvacuum family of freeze-dryers, the LyoPro range has been created following the precise design and control, to manage large batch freeze drying with the same efficiency and exactness as that of small batches.

Compact in size cooling and vacuum systems as well as the use of the best materials, make this equipment a one-of-a-kind piece.

Model LyoPro
Shelf area 16.8 m² 19.2 m² 21.6 m² 24 m² 26.4 m² 28.8 m² 30 m² 33 m² 36 m² 39 m² 42 m² 45 m²
Shelf dimensions (W x D) 1,500 x 1,600 mm 1,500 x 2,000 mm
Nº of shelves 7 8 9 10 11 12 10 11 12 13 14 15
Shelves clearance 105 mm 90 mm 75 mm 105 mm 90 mm 75 mm 105 mm 90 mm 75 mm 105 mm 90 mm 75 mm
Chamber width 2,300 mm 2,300 mm
Chamber height 4,200 mm 4,400 mm 4,600 mm
Condenser capacity  300 kg 350 kg 400 kg 450 kg 450 kg  500 kg 600 kg 800 kg
Condenser temperature -85 ºC
Shelves temperature range from - 60 ºC to +85 ºC

Optional equipment

The chamber

  • Rectangular chamber

  • Pressureless vessel

  • Injected foam insulation

  • Cooling by cold water circuit

Connection with condenser

  • Butterfly valve

  • Mushroom valve

  • Bottom shelf closing

Ice condenser

  • Integrated underneath, on the same floor

  • Integrated on the side, on the same floor

  • Outside, behind the camera, on the same floor

  • Outside, under the camera, on another floor

Shelves movement

  • Closing system hydraulic piston

  • Bellows

  • Connection with the automatic charging system


  • Chamber and condenser cleaning system

  • Recirculation system with heating

  • Multiple cleaning cycles


  • PED-EN13445

  • ASME

  • Chamber cool-down after SIP

Plant distribution

  • 1st floor

  • 2 floors

  • Passthrough system

Additional elements

  • ATEX (processed with solvents and alcohol)

  • Cold tray loading

  • Frozen tray loading

  • Nucleation technology


  • Piston compressor

  • Screw compressor

  • Liquid nitrogen system

  • Cascade system

  • Cooling system without PCA

  • Compressed air system


  • Full size door

  • Automatic locking

  • Slot front door (constant loading level)

  • Full size sub-door

  • Cooling by cold water circuit

Process sensors

  • Pirani

  • Capacitive

  • Temperature probes (Pt-100 / Thermocouple)

  • Redundant temperature probes (Pt-100 / Thermocouple)

  • Wireless temperature monitoring

  • Full batch traceability software

Control systems

  • Rockwell / Siemens Automation PLC

  • Integrated HMI


  • Electronic recorder

  • Electronic Server and Think Client

  • Cycle optimization technology

Filter vent system

  • Sterilizable

  • Ports for integrity testing

  • Secondary venting cycle

  • Secondary vent filter

  • Water filter integrity test

Vacuum system

  • Sealed vacuum pumps with blowing system

  • Redundancy (additional pump)

  • Dry pumps with blowing system

Always at your disposal!

We look forward to assisting you with your projects and answering your questions and suggestions. Fill in this form and we will contact you as soon as possible.

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