Production freeze dryers
Customized compact and effective solutions
Coolvacuum developed a complete range of industrial freeze dryers, with a useful shelf area from 0.5 to 45 m2, to cover different production needs.
With 5 basic models and more than 40 optional features, Coolvacuum freeze dryers can be adapted to the specific needs of our clients.
Using only the best and most reliable materials and components, our equipment complies with the quality levels expected by the advanced pharmaceutical industry.
| Vial loading capacity | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| shelves m2 | 1 | 1.5 | 2 | 3 | 4 | 5 | 6 | 8 | 10 | 12 | 14 | ||||||
|
Ø 16 mm (2R-4R) |
4,440 | 6,660 | 8,880 | 13,320 | 17,760 | 22,200 | 26,640 | 35,520 | 44,400 | 53,280 | 62,160 | ||||||
|
Ø 22 mm (6R-8R) |
2,340 | 3,510 | 4,680 | 7,020 | 9,360 | 11,700 | 14,040 | 18,720 | 23,400 | 28,080 | 32,760 | ||||||
|
Ø 24 mm (10R-15R) |
1,970 | 2,955 | 3,940 | 5,910 | 7,880 | 9,850 | 11,820 | 15,760 | 19,700 | 23,640 | 27,580 | ||||||
|
Ø 30 mm (20R-25R) |
1,250 | 1,875 | 2,500 | 3,750 | 5,000 | 6,250 | 7,500 | 10,000 | 12,500 | 15,000 | 17,500 | ||||||
| shelves m2 | 15 | 18 | 20 | 22 | 24 | 26 | 28 | 30 | 32 | 38 | 45 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ø 16 mm (2R-4R) |
65,000 | 79,920 | 88,800 | 97,680 | 106,560 | 115,440 | 124,320 | 133,200 | 142,080 | 168,720 | 200,000 | ||||||
|
Ø 22 mm (6R-8R) |
35,100 | 42,120 | 46,800 | 51,480 | 56,160 | 60,840 | 65,520 | 70,200 | 74,880 | 88,920 | 105,300 | ||||||
|
Ø 24 mm (10R-15R) |
29,550 | 35,460 | 39,400 | 43,340 | 47,280 | 51,220 | 55,160 | 59,100 | 63,040 | 74,860 | 88,650 | ||||||
|
Ø 30 mm (20R-25R) |
18,750 | 22,500 | 25,000 | 27,500 | 30,000 | 32,500 | 35,000 | 37,500 | 40,000 | 47.500 | 56.250 | ||||||
LyoNano
GMP production equipment - Small batches
During pharmaceutical and biotechnological development, high value-added and personalized configuration products require a highly demanding process in small batches and in full compliance with regulations and procedures.
From 0.5 to 2.5 m² of shelf area
Condenser capacity up to 40 kg
Output for 2R up to 10,000 vials
LyoCompact
GMP production equipment - Small scale production
When production needs require the latest technol-ogy operating under the highest market standards, Coolvacuum LyoCompact is a groundbreaking solution as this range of freeze dryers combines a compact design, the best components, features versatile software and is manu-factured using the latest in engi-neering design.
From 2 to 6 m² of shelf area
Condenser capacity up to 80 kg
Output for 2R up to 28,000 vials
LyoCool
GMP production equipment - Medium scale production
An increase in production volumes is always accom-panied by proportional manufacturing equipment sizing. Here, Coolvacuum offers the LyoCool range that represents a perfect balance between compact design and a cooling system capa-ble of managing large production batches.
From 7 to 15 m² of shelf area Condenser capacity up to 250 kg Output for 2R up to 65,000 vials
LyoPro
GMP production equipment - Large scale production
Do you need a high-performance free dryer for large scale production? Coolvacuum offers a solution for this requirement, the model LyoPro. This freeze dryer enables safe, large-scale freeze drying and has easy-to-install design and maximum flexibility.
From 16 to 45 m² of shelf area Condenser capacity up to 800 kg Output for 2R up to 200,000 vials
LyoPharm
GMP production equipment - Freeze dryers within everyone’s reach
LyoPharm is an excellent example of the balance between the investment made and the benefits obtained.
From 2 to 45 m² of shelf area Condenser capacity up to 800 kg Output for 2R up to 200,000 vialsQuality and performance standards
Performance data
Sublimation rate (kg/h) - from 1 to 35 kg/h
Preparation time between batches (CIP / SIP, drying, cooling) - 8 h
Chamber
Surface roughness - 0.8 µm
System leak rate - 0.008 mbar x l/s
Shelves
Flatness on shelf surface - 1 mm/m
Surface roughness on top side (Ra) (Ra) - 0.8 µm
Surface roughness on bottom side (Ra) - 0.8 - 1.4 µm
Temperature distribution on one shelf - < 1 ºC
Temperature distribution in shelves stack - < 1.5 ºC
Temperature difference between the inlet and outlet of a shelf - < 1 ºC
Condenser
Inner surface of condenser - Mirror
Surface roughness of condenser coil - Cold drawn
Defrosting time - from 20 to 60 min
Evaporation surface ratio vs shelf surface - 0.99 m²/m²
Cooling and heating
Shelves cooling rate from +20 ºC to -40 ºC - 1.5 °C/min
Shelves heating rate from -40 ºC a +60 ºC - 1.5 °C/min
Temperature range during drying - from -50 °C to +60 °C
Condenser cooling rate +20 to -40ºC - 1.5 °C/min
Final condenser temperature- -75 ºC
Vacuum
Final system vacuum - 0.005 mbar
Final vacuum of freeze dryer - 0.01 mbar
Vacuum evacuation time from 1,000 a 0.1 mbar - 30 min
Optional equipment for production freeze dryers
Discover our complete range of equipment for our freeze dryers LyoNano, LyoCompact, LyoCool, LyoPro y LyoPharm.
Production equipment