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LyoPharm

LyoPharm

From 2 to 45 m² of shelf area
Condenser capacity up to 800 kg
Output for 2R up to 200,000 vials

GMP production equipment

Standardized configuration of chamber, condenser, cooling and vacuum systems


External condenser connected by butterfly valve


Side or front maintenance door


 

Freeze dryers within everyone’s reach. Outstanding standarization.

LyoPharm is an excellent example of the balance between the investment made and the benefits obtained.
Coolvacuum has designed and standardized the best configuration for each vial dimension to offer high-performance equipment at affordable prices.
Additionally, the standardiza-tion of its components and con-figurations allows us to manu-facture LyoPharm with reduced delivery times.

Model LyoPharm
Shelf area (m²) 2.16 m² 2.88 m² 3.6 m² 4.32 m² 5.04 m² 5.76 m² 7.2 m² 8.64 m² 10.08 m² 11.52 m² 12.96 m² 14.4 m²
Shelf dimensions (W x D) (mm) 800 x 900 mm 1,200 x 1,200 mm
Nº of shelves 3 4 5 6 7 8 5 6 7 8 9 10
Shelves clearance (mm) 105 mm 90 mm 75 mm 105 mm 90 mm 75 mm 105 mm 90 mm 75 mm 105 mm 90 mm 75 mm
Chamber width (mm) 2,000 mm 2,300 mm
Chamber height (mm) 2,200 mm 2,500 mm 2,500 mm 2,900 mm
Condenser capacity (kg) 40 kg 45 kg 50 kg 65 kg 80 kg  80 kg 120 kg 150 kg 200 kg 200 kg 250 kg 250 kg
Tray dimensions 300 x 400 mm 300 x 400 mm
Condenser temperature (ºC) -85 ºC -85 ºC
Shelves temperature range (ºC) from -60 ºC to +85 ºC from -60 ºC to +85 ºC
Model LyoPharm
Shelf area (m²) 16.8 m² 19.2 m² 21.6 m² 24 m² 26.4 m² 28.8 m² 30 m² 33 m² 36 m² 39 m² 42 m² 45 m²
Shelf dimensions (W x D) (mm) 1,500 x 1,600 mm 1,500 x 2,000 mm
Nº of shelves 7 8 9 10 11 12 10 11 12 13 14 15
Shelves clearance (mm) 105 mm 90 mm 75 mm 105 mm 90 mm 75 mm 105 mm 90 mm 75 mm 105 mm 90 mm 75 mm
Chamber width (mm) 2,500 mm 2,500 mm
Chamber height (mm) 2,500 mm 2,900 mm 3,400 mm 3,400 mm 3,600 mm
Condenser capacity (kg) 300 kg 350 kg 400 kg 450 kg 450 kg  500 kg 600 kg 800 kg
Tray dimensions 300 x 400 mm 300 x 400 mm
Condenser temperature (ºC) -85 ºC -85 ºC
Shelves temperature range (ºC) from -60 ºC to +85 ºC from -60 ºC to +85 ºC

Optional equipment

The chamber

  • Rectangular chamber

  • Pressureless vessel

  • Injected foam insulation

  • Cooling by cold water circuit

Connection with condenser

  • Butterfly valve

  • Mushroom valve

  • Bottom shelf closing

Ice condenser

  • Integrated underneath, on the same floor

  • Integrated on the side, on the same floor

  • Outside, behind the camera, on the same floor

  • Outside, under the camera, on another floor

Shelves movement

  • Closing system hydraulic piston

  • Bellows

  • Connection with the automatic charging system

CIP

  • Chamber and condenser cleaning system

  • Recirculation system with heating

  • Multiple cleaning cycles

SIP

  • PED-EN13445

  • ASME

  • Chamber cool-down after SIP

Plant distribution

  • 1st floor

  • 2 floors

  • Passthrough system

Additional elements

  • ATEX (processed with solvents and alcohol)

  • Cold tray loading

  • Frozen tray loading

  • Nucleation technology

Refrigeration

  • Piston compressor

  • Screw compressor

  • Liquid nitrogen system

  • Cascade system

  • Cooling system without PCA

  • Compressed air system

Door

  • Full size door

  • Automatic locking

  • Slot front door (constant loading level)

  • Full size sub-door

  • Cooling by cold water circuit

Process sensors

  • Pirani

  • Capacitive

  • Temperature probes (Pt-100 / Thermocouple)

  • Redundant temperature probes (Pt-100 / Thermocouple)

  • Wireless temperature monitoring

  • Full batch traceability software

Control systems

  • Rockwell / Siemens Automation PLC

  • Integrated HMI

  • SCADA

  • Electronic recorder

  • Electronic Server and Think Client

  • Cycle optimization technology

Filter vent system

  • Sterilizable

  • Ports for integrity testing

  • Secondary venting cycle

  • Secondary vent filter

  • Water filter integrity test

Vacuum system

  • Sealed vacuum pumps with blowing system

  • Redundancy (additional pump)

  • Dry pumps with blowing system