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LyoPharm

LyoPharm

From 2 to 45 m² of shelf area
Condenser capacity up to 800 kg
Output for 2R up to 200,000 vials

GMP production equipment

Standardized configuration of chamber, condenser, cooling and vacuum systems


External condenser connected by butterfly valve


Side or front maintenance door


 

Freeze dryers within everyone’s reach. Outstanding standarization.

LyoPharm is an excellent example of the balance between the investment made and the benefits obtained.
Coolvacuum has designed and standardized the best configuration for each vial dimension to offer high-performance equipment at affordable prices.
Additionally, the standardiza-tion of its components and con-figurations allows us to manu-facture LyoPharm with reduced delivery times.

ModelLyoPharm
Shelf area (m²)2.16 m²2.88 m²3.6 m²4.32 m²5.04 m²5.76 m²7.2 m²8.64 m²10.08 m²11.52 m²12.96 m²14.4 m²
Shelf dimensions (W x D) (mm)800 x 900 mm1,200 x 1,200 mm
Nº of shelves3456785678910
Shelves clearance (mm)105 mm90 mm75 mm105 mm90 mm75 mm105 mm90 mm75 mm105 mm90 mm75 mm
Chamber width (mm)2,000 mm2,300 mm
Chamber height (mm)2,200 mm2,500 mm2,500 mm2,900 mm
Condenser capacity (kg)40 kg45 kg50 kg65 kg80 kg 80 kg120 kg150 kg200 kg200 kg250 kg250 kg
Tray dimensions300 x 400 mm300 x 400 mm
Condenser temperature (ºC)-85 ºC-85 ºC
Shelves temperature range (ºC)from -60 ºC to +85 ºCfrom -60 ºC to +85 ºC
ModelLyoPharm
Shelf area (m²)16.8 m²19.2 m²21.6 m²24 m²26.4 m²28.8 m²30 m²33 m²36 m²39 m²42 m²45 m²
Shelf dimensions (W x D) (mm)1,500 x 1,600 mm1,500 x 2,000 mm
Nº of shelves789101112101112131415
Shelves clearance (mm)105 mm90 mm75 mm105 mm90 mm75 mm105 mm90 mm75 mm105 mm90 mm75 mm
Chamber width (mm)2,500 mm2,500 mm
Chamber height (mm)2,500 mm2,900 mm3,400 mm3,400 mm3,600 mm
Condenser capacity (kg)300 kg350 kg400 kg450 kg450 kg 500 kg600 kg800 kg
Tray dimensions300 x 400 mm300 x 400 mm
Condenser temperature (ºC)-85 ºC-85 ºC
Shelves temperature range (ºC)from -60 ºC to +85 ºCfrom -60 ºC to +85 ºC

Optional equipment

The chamber

  • Rectangular chamber

  • Pressureless vessel

  • Injected foam insulation

  • Cooling by cold water circuit

Connection with condenser

  • Butterfly valve

  • Mushroom valve

  • Bottom shelf closing

Ice condenser

  • Integrated underneath, on the same floor

  • Integrated on the side, on the same floor

  • Outside, behind the camera, on the same floor

  • Outside, under the camera, on another floor

Shelves movement

  • Closing system hydraulic piston

  • Bellows

  • Connection with the automatic charging system

CIP

  • Chamber and condenser cleaning system

  • Recirculation system with heating

  • Multiple cleaning cycles

SIP

  • PED-EN13445

  • ASME

  • Chamber cool-down after SIP

Plant distribution

  • 1st floor

  • 2 floors

  • Passthrough system

Additional elements

  • ATEX (processed with solvents and alcohol)

  • Cold tray loading

  • Frozen tray loading

  • Nucleation technology

Refrigeration

  • Piston compressor

  • Screw compressor

  • Liquid nitrogen system

  • Cascade system

  • Cooling system without PCA

  • Compressed air system

Door

  • Full size door

  • Automatic locking

  • Slot front door (constant loading level)

  • Full size sub-door

  • Cooling by cold water circuit

Process sensors

  • Pirani

  • Capacitive

  • Temperature probes (Pt-100 / Thermocouple)

  • Redundant temperature probes (Pt-100 / Thermocouple)

  • Wireless temperature monitoring

  • Full batch traceability software

Control systems

  • Rockwell / Siemens Automation PLC

  • Integrated HMI

  • SCADA

  • Electronic recorder

  • Electronic Server and Think Client

  • Cycle optimization technology

Filter vent system

  • Sterilizable

  • Ports for integrity testing

  • Secondary venting cycle

  • Secondary vent filter

  • Water filter integrity test

Vacuum system

  • Sealed vacuum pumps with blowing system

  • Redundancy (additional pump)

  • Dry pumps with blowing system

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