Access to the multimedia content of the products.



From 16 to 45 m² of shelf area
Condenser capacity up to 800 kg
Output for 2R up to 200,000 vials

GMP production equipment for large scale production

External condenser in 1 or 2 floor configuration

Mushroom or butterfly valve as intermediate valve

Continuous circular coil in condenser

Standalone frame for cooling system

Standalone frame for vacuum system

Maximum performance. Large-scale security and reliability.

Do you need a high-performance freeze dryer for large scale production? Coolvacuum offers a solution for this requirement, the model LyoPro. This freeze dryer enables safe, large-scale freeze drying and has easy-to-install design and maximum flexibility.

As the flagship of the Coolvacuum family of freeze-dryers, the LyoPro range has been created following the precise design and control, to manage large batch freeze drying with the same efficiency and exactness as that of small batches.

Compact in size cooling and vacuum systems as well as the use of the best materials, make this equipment a one-of-a-kind piece.

Shelf area16.8 m²19.2 m²21.6 m²24 m²26.4 m²28.8 m²30 m²33 m²36 m²39 m²42 m²45 m²
Shelf dimensions (W x D)1,500 x 1,600 mm1,500 x 2,000 mm
Nº of shelves789101112101112131415
Shelves clearance105 mm90 mm75 mm105 mm90 mm75 mm105 mm90 mm75 mm105 mm90 mm75 mm
Chamber width2,300 mm2,300 mm
Chamber height4,200 mm4,400 mm4,600 mm
Condenser capacity 300 kg350 kg400 kg450 kg450 kg 500 kg600 kg800 kg
Condenser temperature-85 ºC
Shelves temperature rangefrom - 60 ºC to +85 ºC

Optional equipment

The chamber

  • Rectangular chamber

  • Pressureless vessel

  • Injected foam insulation

  • Cooling by cold water circuit

Connection with condenser

  • Butterfly valve

  • Mushroom valve

  • Bottom shelf closing

Ice condenser

  • Integrated underneath, on the same floor

  • Integrated on the side, on the same floor

  • Outside, behind the camera, on the same floor

  • Outside, under the camera, on another floor

Shelves movement

  • Closing system hydraulic piston

  • Bellows

  • Connection with the automatic charging system


  • Chamber and condenser cleaning system

  • Recirculation system with heating

  • Multiple cleaning cycles


  • PED-EN13445

  • ASME

  • Chamber cool-down after SIP

Plant distribution

  • 1st floor

  • 2 floors

  • Passthrough system

Additional elements

  • ATEX (processed with solvents and alcohol)

  • Cold tray loading

  • Frozen tray loading

  • Nucleation technology


  • Piston compressor

  • Screw compressor

  • Liquid nitrogen system

  • Cascade system

  • Cooling system without PCA

  • Compressed air system


  • Full size door

  • Automatic locking

  • Slot front door (constant loading level)

  • Full size sub-door

  • Cooling by cold water circuit

Process sensors

  • Pirani

  • Capacitive

  • Temperature probes (Pt-100 / Thermocouple)

  • Redundant temperature probes (Pt-100 / Thermocouple)

  • Wireless temperature monitoring

  • Full batch traceability software

Control systems

  • Rockwell / Siemens Automation PLC

  • Integrated HMI


  • Electronic recorder

  • Electronic Server and Think Client

  • Cycle optimization technology

Filter vent system

  • Sterilizable

  • Ports for integrity testing

  • Secondary venting cycle

  • Secondary vent filter

  • Water filter integrity test

Vacuum system

  • Sealed vacuum pumps with blowing system

  • Redundancy (additional pump)

  • Dry pumps with blowing system

No videos so far

No brochures so far